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DC Field | Value | Language |
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dc.contributor.author | Sydorchuk, L.P. | en |
dc.contributor.author | Ursuliak, U.V. | en |
dc.contributor.author | Sydorchuk, A. | en |
dc.contributor.author | Makoviychuk, I. | en |
dc.contributor.author | Trutiak, V. | en |
dc.contributor.author | Biryuk, I.G. | en |
dc.date.accessioned | 2015-05-20T05:36:01Z | |
dc.date.available | 2015-05-20T05:36:01Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/8879 | |
dc.description.abstract | The dynamics of endothelial dysfunction (ED) humoral factors: a soluble form of vascular cell adhesion molecule 1 (sVCAM-1), total NO metabolites and systemic inflammatory response - C-reactive protein (CRP) in patients with acute myocardial infarction (MI) under the influence of treatment and depending on genes polymorphism – angiotensin converting enzyme (ACE, I/D) and endothelial nitric oxide synthase (eNOS, T894G) were evaluated. The presence of DD-genotype of ACE gene is associated with a significantly greater decrease of sVCAM-1 and CRP levels under the influence of treatment (better with thrombolytic therapy (TLT), p<0.05); in T- allele carriers of eNOS gene the level sVCAM-1 under TLT decreased by 30.7-31.2%. Content of NO metabolites decreased more in D-allele carriers of ACE gene as well as after combined treatment with TLT (39.1% and 35.2%) and did not depend on the allele state of eNOS gene. | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | The Pharma Innovation-Journal | ru_RU |
dc.subject | ACE (I/D) | ru_RU |
dc.subject | eNOS (894G>T) genes | ru_RU |
dc.subject | myocardial infarction | ru_RU |
dc.subject | endothelium | ru_RU |
dc.subject | treatment | ru_RU |
dc.title | Humoral markers of endothelial dysfunction and systemic inflammatory response in patients with acute myocardial infarction depending on genes polymorphism of ACE (I/D) and eNOS (894G>T) | ru_RU |
dc.type | Other | ru_RU |
Appears in Collections: | Статті. Кафедра сімейної медицини |
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