Pharmacological correction of endothelial dysfunction in patients with HIV-infection/AIDS

Abstract

On the basis of inspection 127 patients with HIV-infection/AIDS it has been established that in case of this pathology the concentration of thrombomodulin, Е-selectin and von Willebrand’s factor substantially grows, which is indicative of a HIV-induced affection of the vascular wall. As immunodeficiency progresses, the concentration of all the mentioned indices grows significantly. 3-month symptomatic therapy does not influence on the state of the endothelium. The use of the dipiridamol, aggregant, and also a 3-month antiretroviral treatment of the first row provide only a partial decline of the thrombomodulin, Е-selectin and von Willebrand’s factor levels. However, the inclusion to the antiretroviral therapy (ART) of dipiridamol maximally optimizes the endothelial state of the endothelium: the level of thrombomodulin and von Willebrand’s factor at the IInd clinical stage of HIV-infection normalizes and at the IIId-IVth stages – significantly lowers, although it does not reach the values of healthy persons. The same ponderable difference is established in relation to the content of Е-selectin.