Mueller-matrix microscopy of laser-induced monochromatic fluorescent fields of preparations of human internal organs and histological diagnostics of the time of age of damage formation

Abstract

Abstract. The article contains the results of experimental testing of methods of azimuthal-invariant Mueller-matrix microscopy (Mueller-matrix invariants – MMI) of optically anisotropic fluorophores of samples of histological sections of the brain, liver and kidney, as well as myocardium and lung tissue; temporal detection of variations in the magnitude of the statistical moments of the 1st - 4th orders, characterizing the distributions of the MMI value of linear birefringence and optical activity of samples of histological sections of the brain, liver and kidney, as well as myocardium and lung tissue with different age of damage; determination of the diagnostic efficiency (time interval and accuracy) of establishing the age of damage to human internal organs by digital histological methods of MMI mapping of optical anisotropy of fluorophores in histological sections of the brain, liver and kidney, as well as myocardium and lung tissue.