Multichannel polarization sensing of polycrystalline blood films in the diagnosis of the causes of poisoning

Abstract

Abstract. The results of a study of the effectiveness in the differential diagnosis of cases of alcohol and carbon monoxide poisoning by azimuthally invariant polarizing Mueller-matrix microscopy are presented: a) multichannel sounding with differently polarized laser beams of histological sections of the brain, myocardium, adrenal glands, liver and polycrystalline blood films of the dead and multichannel polarization filtering of a series of microscopic images with algorithmic determination of coordinate distributions (maps): 1. Muller-matrix invariants of linear birefringence of fibrillar networks (MMI LB); 2. Mueller-matrix invariants of circular birefringence of optically active molecular complexes (MMI CB); b) statistical differentiation of MMI LB and MMI CB cards with the optically anisotropic component of histological sections of the brain, myocardium, adrenal glands, liver and polycrystalline blood films of the dead due to IHD (control group), alcohol poisoning (study group 1) and carbon monoxide (study group 2); c) determination of operational characteristics (sensitivity, specificity and balanced accuracy) of the strength of the multidimensional Mueller-matrix microscopy method for histological sections of the brain, myocardium, adrenal glands, liver and polycrystalline blood films of the dead of all groups.