Angiotensinogen (AGT RS4762) and guanine nucleotide-binding protein BETA-3 (GNB3 RS5443) genes predict left ventricular hypertrophy in hypertensive patients

Abstract

Abstract. This study aims to evaluate polymorphic variants of AGT (rs4762) and GNB3 (rs5443) genes as predictors of myocardium left ventricular hypertrophy (LVH) in patients with essential arterial hypertension (EAH). The case-control study involved 100 patients with EAH stage II, high-very high cardiovascular risk. There were 21% men, and 79% women; the average age was 59.86±6.22 years old. The control group consisted of 60 practically healthy subjects. AGT (rs4762) and GNB3 (rs5443) genotyping was performed by Real-Time PCR. As a result, centric LVH (ELVH) in EAH patients is more common in T-allele carriers of AGT gene (rs4762), CC-genotype subjects of GNB3 gene (rs5443) by 26.29% and 22.22%, respectively. Concentric LVH (CLVH) dominates in homozygous C-allele patients of AGT gene (rs4762), and T-allele of GNB3 gene (rs5443) by 29.13%, 22.22%, correspondingly. ELVH risk increases in hypertensive T-allele carriers of AGT gene (rs4762) 4.5 times and in CC-genotype of GNB3 gene (rs5443) almost 5 times. CLVH risk increases in CC-genotype patients of AGT gene (rs4762) almost 5 times, in T-allele of GNB3 gene more than 4 times. Blood pressure (BP) ≥160/≥100mmHg increases ELVH risk 3 times. In conclusion, LV hypertrophic models associate with AGT (rs4762) and GNB3 (rs5443) genes polymorphic variants in hypertensive patients, as well as ELVH with BP elevation.