Morphological features of bone tissue in "disuse atrophy" on the example of a segment of the human lower jaw: clinical experience of treatment

Abstract

Current real-time science and technology techniques based on ENDORET PRGF technologies and the implementation of their results in practical medicine, provide ample opportunities for the use of cell autotransplantation for guided tissue regeneration, including in the treatment of "disuse atrophy" of the human lower jaw bone tissue with early tooth loss. The purpose of this work is to ensure the principles of biological feasibility and physiological capacity, technical rationality. The pathology in the distal segment of a lower limb, which is a vertical atrophy of bone tissue was confirmed by the methods of computed tomography, Vatech PaX-I 3D Green systems of extra-oral radiography with a scan size range of 16x9 cm, a focal spot of 0.5 mm (IEC60336) with a gray scale of 14 bits with a size of 0.2/0.3 voxel. Using ENDORET PRGF technology, according to the approved BTI protocol, autocellular grafts that have provided a positive result that meets the basic principles of the goal in restoring the mechanisms of physiological processes of normal quantitative and qualitative morphology of bone tissue, with its biological characteristics were obtained. The results of the study showed that bone tissue on a scale of shades of gray based on the classification of Hounsfield, is not characterized by a single biotype and in the area of missing 3.6 tooth belongs to the second biotype, and in the area of missing 3.7 tooth - to the first biotype by its density. The indicators of densitometric determination confirmed excessive mineralization of the trabecular layer, ie vertical atrophy of bone tissue, which is in the sagittal section in the projection of the missing 36 teeth - with a maximum number of 881 gray standard units (GSU), M=315 GSU (where, M is the average value of absolute number); sagittal section in the projection of the missing 37 teeth - with a maximum number of 1726 GSU, M=1173 GSU. This clinical experience with the use of autocellular grafts in the treatment of "disuse atrophy" of the bone tissue of the jaws, which is essentially scientifically-research in nature, based on modern, at the same time available technologies of cell engineering and technical progress, provides a predictable result of clinical observation and deserves further research and practical testing.