Please use this identifier to cite or link to this item: http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/25916
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKotsyubiychuk, Z.Y.-
dc.contributor.authorAntoniv, A.A.-
dc.contributor.authorMakhrova, E.G.-
dc.contributor.authorVivsyannuk, V.V.-
dc.contributor.authorTsariuchenko, D.S.-
dc.contributor.authorКоцюбійчук, Зоряна Ярославівна-
dc.contributor.authorАнтонів, Альона Андріївна-
dc.contributor.authorМахрова, Євгенія Григорівна-
dc.contributor.authorВівсянник, Володимир Васильович-
dc.contributor.authorЦарюченко, Д.С.-
dc.date.accessioned2024-11-12T13:45:53Z-
dc.date.available2024-11-12T13:45:53Z-
dc.date.issued2021-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/25916-
dc.description.abstractSummary. It was found that the comorbid course of nonalcoholic steatohepatitis and diabetic kidney disease in patients with type 2 diabetes mellitus is accompanied by a significant increase in the intensity of oxidative stress, accompanied by an increase in blood intermediate and final products of lipid peroxidation, lipid and oxidation. 3 times (p <0.05). The damaging effect of oxidative stress in patients with type 2 diabetes mellitus leads to the activation of apoptosis of hepatocytes with an increase in blood cytokeratin-18 (7.5 times, p <0.05), the content of which correlates with the degree of oxidative stress, the intensity of liver damage and stage of diabetic kidney disease (p <0.05). Oxidative stress increases the risk of endothelial damage by atherosclerotic process due to hyperproduction of homocysteine (3.9 times, p <0.05), which contributes to the progression of diabetic kidney disease. The use of quercetin in the complex therapy of non-alcoholic steatohepatitis and type 2 diabetes mellitus with diabetic kidney disease contributes to the probable reduction of oxidative stress, increased activity of antioxidant defense factors (content of reduced glutathione in erythrocytes, reduction of cytokeratin-18 content by 1.7 times) and endothelial damage (reduction of homocysteine content in blood by 1.9 times) (p <0.05). The comorbid course of nonalcoholic steatohepatitis and diabetic kidney disease in patients with type 2 diabetes mellitus is accompanied by a significant increase in the intensity of oxidative stress, accompanied by an increase in the content of intermediate and final products of lipid peroxidation and oxidative modification (p <0.05).uk_UA
dc.language.isoenuk_UA
dc.publisherColloquium-journaluk_UA
dc.subjectnon-alcoholic steatohepatitisuk_UA
dc.subjecttype 2 diabetes mellitusuk_UA
dc.subjectdiabetic kidney diseaseuk_UA
dc.subjectoxidative-antioxidant homeostasisuk_UA
dc.subjectapoptosisuk_UA
dc.subjectatherosclerosisuk_UA
dc.subjectquercetinuk_UA
dc.titleThe oxidative stress which is a universal mechanism of tissue damage in non-alcoholic steatogepatitis and those diabetic kidney diseasesuk_UA
dc.typeArticleuk_UA
Appears in Collections:Статті

Files in This Item:
File Description SizeFormat 
Kotsiubiichuk et al. The oxidative.pdf501.6 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.