Current approaches to interpretation of laboratory criteria of severity and prognosis of patients with HIV/AIDS

Abstract

Lately more and more crucial diagnostic methods of the functional state of endothelium in liver disease, chronic obstructive pulmonary diseases, coronary heart disease, diabetes, hypertension and others assume ever greater topicality. The data obtained are useful for assessing the degree of severity of disease and to monitor therapeutic measures. However, there are no information in the literature devoted to studying the functional state of endothelium in HIV-infection/AIDS. So far, the search for fundamentally new approaches to integrated diagnosis of endothelial dysfunction in patients with HIV/AIDS and investigation of their relationship with severity, presence of opportunistic infections is continued. We know that it is quite different from the traditional approach to studying the functional state of endothelial vascular wall - definition of blood substances that are synthesized in endothelial cells and secreted them in the lumen, and consequently in circulating blood. Thus the questions of diagnosis and prognosis of HIV/AIDS remain urgent and require further research.