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dc.contributor.authorChornous, V.A.-
dc.contributor.authorGrozav, A.N.-
dc.contributor.authorVovk, M.V.-
dc.date.accessioned2012-06-27T19:37:58Z-
dc.date.available2012-06-27T19:37:58Z-
dc.date.issued2012-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/2348-
dc.description.abstractAryl-2,4-dichloro-5-formylimidazoles by a successive treatment with hydroxylamine and thionyl chloride were converted into 1-aryl-2,4-dichloroimidazole-5-carbonitriles which by the action of sodium azide and tin(II) chloride were transformed into 2-amino-1-aryl-4-chloroimidazole-5-carbonitriles. The consecutive reactions of 2-azido-1-aryl-4-chloro-5-formylimidazoles with N-bromosuccinimide, methanol, or amides led to the formation of methyl esters and amides of 2-azido-1-aryl-4-chloroimidazole-5-carboxylic acids. The reduction of the latter with tin(II) chloride resulted in the corresponding derivatives of 2-amino-1-aryl-4-chloroimidazole-5-carboxylic acids, and the reduction of 2-azido-1-aryl-4-chloroimidazole-5-carboxylic acids was accompanied with decarboxylation and yielded 2-amino-1-aryl-4-chloroimidazoles.ru_RU
dc.language.isoenru_RU
dc.publisherRussian Journal of Organic Chemistryru_RU
dc.titlePolyfunctional imidazoles: VI. Synthesis of 2-amino-1-aryl-4-chloro-1H-imidazole-5-carboxylic acids derivativesru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра медичної та фармацевтичної хімії

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