Peculiarities of renal mechanisms of carbohydrate status regulation in the early period of experimental diabetes with underlying pharmacological blockade of renin-angiotensin-aldosterone system

Abstract

Based on the pathophysiology of renin-angiotensin-aldosterone system (RAAS), its multifactorial influence on the renal functions obviously requires a detailed study at different stages of nephropathy progression in order to identify pathological factors that are directly promoted by RAAS, and the processes that are hemodynamic consequences of its influence. Specific attention is attracted to the investigation of RAAS involvement in the regulation of renal mechanisms of glucose transport in case of diabetic kidney.