Nephrotropic effects of emoxipine under the conditions of chronic hypoxic hypoxia

Abstract

Free radical oxidation is the most important regulator of lipid and protein metabolism. The result of the intensification of free-radical oxidation, conditions for which are created even in hypoxia, is an increase in the content of its primary, secondary and final products, which are powerful pro-oxidants that intensify free-radical oxidation with the development of the «snow avalanche» phenomenon. However, the influence of hypoxia on numerous physiological and biochemical processes in tissues and cells is twofold and directed opposite. The most promising drugs for the correction of hypoxic conditions are antihypoxants – drugs capable of smoothing the energy deficit and preventing the destruction of cell membranes by free radicals using various mechanisms. Emoxipine, a derivative of 3-oxypyridine, attracts special attention in this matter.