Morphological changes of kidney tissue when using hepaval in ischemia-reperfusion acute kidney injury

Abstract

Ischemia-reperfusion injury, which is usually caused by trauma, sepsis, kidney transplantation, exposure to toxic substances, primarily affects the structure and function of the cells of the tubular epithelium, which is accompanied by microcirculation dysfunction, the development of hypoxia, oxidative stress and inflammatory reactions, which further leads to necrosis and apoptosis of nephrocytes. The pharmacotherapy of I/R AKI includes agents capable of preventing the occurrence of irreversible morphofunctional changes, as well as exhibiting antioxidant and anti-inflammatory activity. A hepatoprotector with antioxidant and detoxifying properties – Hepaval, became the drug of choice for the correction of morphological changes in I/R AKI.