Detoxification resources of kidneys in sepsis

Abstract

Microorganisms and products of their vital activity, bacterial endo- and exotoxins, intermediary and terminal products of the metabolism (in excessive concentrations), components of the cellular, tissue, organic and integration regulatory systems (in pathologically high concentrations), products of the distorted metabolism, toxic substances of the intestinal origin are generally referred to the factors of endogenic intoxication. Molecules of the average mass (MAM), which have sufficiently high biological activity, are also referred to composition of toxic substances. In particular, they have neurotoxic, cardiotoxic, hepatotoxic, nephrotoxic activity, induce secondary immunosuppression.