Prognostic value of plasma cystatin c as an early biomarker of severe kidney dysfunction in critically ill preterm newborns

Abstract

Recent decades have been marked by significant progress in the development of technologies for raising babies born before the physiological term, in particular, in newborns with low and very low birth weight. However, the burden of disease among children of the above-mentioned groups has increased significantly, including due to the development of a significant number of complications against the background of combined perinatal pathology. Acute kidney injury (AKI) is one of the critical conditions of the early neonatal period, and, according to the literature, the incidence rates among premature patients in the departments of anesthesiology and neonatal intensive care are 18-56% (Askenazi D.J., 2020, Selewski D.T., 2015) . Thus, the main problem of modern neonatal nephrology will remain the study of highly specific and sensitive biomarkers of renal dysfunction, which would make it possible to form a risk group among patients at the preclinical stage.