Polymorphism N34S of the SPINK1 gene in ukrainian patients with different forms of acute pancreatitis

Abstract

The course of acute pancreatitis, whose onset is stipulated by one and the same factor, may be of quite an opposite nature in different patients - from the edematous form to pancreatonecrosis. It directly depends on the marked character of the aggressive influence of activated aggressive enzymes on the pancreas and its surrounding tissues (9). Here, an important role is played by genetically determined defense mechanisms aimed at preventing an intrapancreatic activation of enzymes (1-10). One of the such fundamental mechanisms is the neutralizing effect of the secretory pancreatic trypsin inhibitor (the serine protease inhibitor of Kazal’s type I - SPINK1).