Vascular endothelial dysfunction and hemostasis of patients with copd and type 2 diabetes

Abstract

Chronic obstructive pulmonary disease (COPD), a chronic inflammatory disease, mainly with lesions of the peripheral respiratory system with development of emphysema, manifested by irreversible bronchial obstruction, has a progressive nature with the subsequent development of pulmonary insufficiency and chronic pulmonary heart disease. Diabetes mellitus (DM) also remains a very important problem in Ukraine today, as its incidence has increased by 10% in the last 2 years. In 2010, more than 1 million patients with diabetes were registered in Ukraine, including 870 thousand patients with type II diabetes. The study of a comorbid course of COPD and diabetes has a long history. Although the combination of COPD with diabetes is common, there is no comprehensive information in the literature concerning this problem, in particular on the pathogenic role of vascular endothelial dysfunction and the state of the hemostasis system.