Impact of adaptation disorders on the functional state of the hepatobiliary system in newborn with perinatal pathology

Abstract

The presence of hypoxic exposure in the perinatal period has an adverse effect on the adaptation of a newborn's body. Against the background of hypoxia, significant dysmetabolic changes occur in the fetus already in uterus, which is a consequence of the disorders of the liver function. Insufficient supply of oxygen to the fetal body against the background of placental insufficiency causes activation of anaerobic glycolysis, impaired ATP utilization, inhibition of lipolysis, development of hypoglycemia, hypoinsulinemia, and hyperglucagonemia. During the implementation of perinatal risk factors during childbirth, the increased damaging effect on the body of the consequences of oxidative stress (OS) is noted.