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Title: | Impaired glucose tolerance in the blood of alloxan diabetic rats under long term melatonin injections |
Authors: | Kushnir, О.Yu. |
Issue Date: | 2023 |
Publisher: | Буковинський державний медичний університет |
Abstract: | An increasing number of studies have shown that melatonin, as the main product secreted by the pineal gland, plays a vital role in the occurrence and development of diabetes. Melatonin ameliorates hypertrophic growth of the myocardium induced by hyperthyroidism and provides an insight into the mechanism of reactive oxygen species-mediated downregulation of metabolically important genes such as GLUT4 in the heart. There is evidence that impaired glucose tolerance (IGT) is a risk factor for cardiovascular disease. Melatonin and its metabolites have potent antioxidant/anti-inflammatory properties, and they have proven to be highly effective in a variety of disorders linked to inflammation and oxidative stress. Hyperglycemia-mediated oxidative stress plays a crucial role in diabetic complications. |
URI: | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/20926 |
ISSN: | 978-617-519-019-7 |
Appears in Collections: | СЕКЦІЯ 5. Актуальні питання біологічної та фармацевтичної хімії |
Files in This Item:
File | Description | Size | Format | |
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Kushnir О.Yu._2023_72-3.pdf | 433.58 kB | Adobe PDF | View/Open |
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