Morphological changes in the structural elements of the kidneys under the combined influence of aluminum and lead salts against the background of stress

Abstract

Aluminum and lead significantly affect functions of human organs and systems, rank first in toxicity, and can damage kidneys. Taking into account the results of our studies, seeding rats with doses of these toxic metals significantly alters functional state of kidneys. In particular, loss of electrolytes, disturbance of acid-excretory function, which is mainly due to the damage of proximal parts of nephrons with subsequent development of decompensated systemic acidosis and a large deficiency of buffer bases in blood due to a significant reduction of sodium-dependent regeneration of a bicarbonate buffer.