Application of immunohistochemical methods of investigation for choosing treatment tactic

Abstract

Introduction. Many studies include apoptotic processes in the pathogenesis of nodular goiter on the background of autoimmune thyroiditis (AIT). However, data about the markers involved in the regulation of apoptosis and proliferation in thyroid gland parenchyma in AIT are not sufficiently studied and sometimes are contradictory, which requires some systematization in order to optimize the diagnosis and next method of treatment. Therefore, morphological and immunocytochemical studies of thyroid puncture material are performed on individual drugs, which lead to additional puncture biopsies and make the morphological identification impossible. The best option for preoperative cytological diagnosis of thyroid pathology is the sequential cytomorphological and immunocytochemical examination of the same smear of puncture material. The main treatment of autoimmune thyroiditis (AIT) is conservative. The objective of the study was to determine the choice of surgery volume in patients with nodular goiter and AIT, taking into account the activity of apoptosis, index of proliferative activity.