Effect of melatonin drugs on the dynamics of lipid profile indicators in patients with arterial hypertension and osteoarthritis

Abstract

Annotation. Hypertension (AH) and osteoarthritis (OA) are among the most common diseases in the world, which not only negatively affect the quality of life of patients, but also cause an increase in economic costs for health care. Group I patients who received melatonin during the month on the background of the main treatment have better dynamics of lipid profile compared with the corresponding indicators in group II patients. Thus, the level of cholesterol decreased in group I by 13,5%, and in group II – by 12,0%; LDL indicators decreased in group I by 29,2%, and in group II – by 21,4%. At the same time, the indicators of HDL and CA in patients of two groups (I and II) with hypertension combined with OA, were practically unchanged. The addition of melatonin (3 mg once daily at bedtime for 1 month) to the main therapy has a positive effect on the normalization of lipid metabolism in patients with hypertension associated with osteoarthritis, and facilitates their severe course. Further research will help to optimize the treatment tactics of such patients.