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dc.contributor.authorTiulienieva, Оlena А.
dc.contributor.authorTsagkaris, Christos
dc.contributor.authorDavydenko, I.S.
dc.contributor.authorHoian, Аnastasiia V.
dc.contributor.authorYasnikovska, Svitlana M.
dc.contributor.authorHovornyan, Serhiy L.
dc.date.accessioned2022-06-22T12:00:14Z
dc.date.available2022-06-22T12:00:14Z
dc.date.issued2021
dc.identifier.otherDOI:10.4103/jmedsci.jmedsci_217_20
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/20205
dc.description.abstractObjective: Iron deficiency anemia (IDA) in pregnancy is challenging, inducing a systemic pathological process in women's bodies. In this context, impaired protein metabolism, decreased respiratory enzyme activity, limitation of cells' proliferative potential, oxidative stress, hypoxia, and endothelial dysfunction affect the "mother-placenta-fetal" system. However, several features of this pathogenetic cascade, including the spread of extravillous cytotrophoblasts (ECT), are yet to be investigated. This research aimed to study the immunohistochemical features and quantitative indicators of ECT spread throughout the uteroplacental bed (UPB) in IDA at 37–40-week gestation. Conclusions: It is established that, during gestation with IDA, a deepening of CT invasion in the structure of the UPB, an increase in the lining distance of the endothelium-replacing CT in the artery walls, and consequently, a dilatation of spiral and radial arteries takes place in the uterus of pregnant women. However, the invasive ability and synthetic activity of the CT and as a result, the adequacy of the gestational transformation of UPB structures are affected by the hypoxia and depend on the degree of IDA of pregnant women.uk_UA
dc.language.isoenuk_UA
dc.publisherJournal of Medical Sciencesuk_UA
dc.subjectuteroplacental beduk_UA
dc.subjectcytotrophoblast invasionuk_UA
dc.subjectextravillous cytotrophoblastsuk_UA
dc.subjectmetalloproteinasesuk_UA
dc.subjectiron-deficiency anemia in pregnancyuk_UA
dc.subjectgynecologyuk_UA
dc.titleImmunohistochemical Evaluation of Extravillous Cytotrophoblasts in the Uteroplacental Bed in Iron-deficiency Anemia of Pregnancyuk_UA
dc.typeArticleuk_UA
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