Зміни концентрації в плазмі крові маркерів апоптозу ендотеліоцитів у хворих на вегето-судинну дистонію та методи їх корекції

Abstract

It has been established that in patients with vegetovascular dystonia after the hypertensive type the blood content of sCD95 molecules decreases and the sCD117 level increases that is accompanied by a reliable elevation of the caspase-1 activity, however, the activity of caspases-3 and -8, as well as the blood content of sFas-l do not change. Multimodality treatment, employing glutargin decreases the plasma content of sCD95 by 28 %, normalizes the blood sCD117 level and does not influence on the sFas-l concentration and the activity of caspases-1,-3,-8 in the blood plasma. With vegetovascular dystonia after the hypotensive type the blood plasma concentration of sCD95, sFas-l and the activity of caspases-1,-3,-8 correspond to the control value against a background of an elevation of the plasma concentration of sCD117 by 91 %. The use of erbisol in the treatment does not change the plasma concentration of sCD95, sFas-l and the activity of caspases-1,-3,-8 and diminishes the blood content of sCD95 up to control values. The blood plasma concentration of the molecules of sCD95, sFas-l and a dissolved form of the factor of stem cells – sCD117 molecules increases statistically significantly in patients with VVD after the mixed type as compared with the control groups of subjects that is accompanied with a reliable elevation of caspases-1,-3,-8. The combined effects of glutargin and erbisol in patients of this group are characterized by a decrease (but not a normalization) of the blood content of sCD95 by 45 %, sFas-l by – 46 %, sCD117 – by 47 % and a decrease of the activity of caspases-1,-3,-8.