EMBRYOLOGIC PRECONDITIONS OF SOME CONGENITAL MALFORMATIONS OF COMMON BILE DUCT

Abstract

In order to identify the morphological preconditions of some congenital malformations of the biliary system, the research of the peculiarities of prenatal morphogenesis of the common bile duct (CBD)has been performed on 72 series of sequential histologic sections of human embryos and prefetuses, also on 50 cadavers of human fetuses by means of the methods of microscopy, morphometry, macroscopic and microscopic preparation, graphic reconstruction. Statistical analysis of the results of research was carried out with calculation t-test. It has been established that the stage of embryonal occlusion of CBD from the 6th till the 8th weeks in the embryos 8,5-24 mm in in parietal-coccygeal length is a morphologic substrate for congenital biliary atresia. Deceleration of CBD growth and the diverticulum-like dilatation of last one at the beginning of the 4th month and during the 8th month of the human intrauterine development can become the morphologic predictors for the formation of congenital dilatation and cysts of this anatomic structure.