ПРОФИЛАКТИКА АНТИДИСБИОТИЧЕСКИМ СРЕДСТВОМ КВЕРТУЛИН НЕАЛКОГОЛЬНОГО СТЕАТОГЕПАТИТА (НАСГ) У КРЫС

Abstract

Aim: To determine the prophylactic action of quertulin on the experimental non-alcohol steatohepatitis (NASH). Materials and methods: NASH reproduced in rats by feeding with the feed with 15 % palm oil and lincomycin with drink water. The antidysbiotic means quertulin (quercetin + inuline + citrate Ca) were used in dose 300 mg/kg during 40 days. As control the ration with 15 % high oleic acid sunflower oil was used. The increase of rat veigt, the contents of lipide were determined in liver and serum. The activity of urease and lysozyme were determined in gut mucosa. The activity of ALT was determined in serum. Results: The ration with palm oil increased the rat weight and the fat content of liver in 1,8 time compare with the ration with high-oleic acid sunflower oil. The degree of dysbiosis in gut mucosa and serum increased at NASH. Quertulin made prophylaxis of NASH. Conclusion: The feeding of palm oil and the intestinal dysbiosis reproduce NASH, what may be notify by quertulin. НАСГ вызывали у крыс путем кормления рационом с пальмовым маслом на фоне кишечного дисбиоза. Ввод антидисбиотического средства квертулина предупреждал развитие НАСГ. НАСГ викликали у щурів шляхом годівлі раціоном з вмістом пальмової олії на тлі кишкового дисбіозу. Введення антидисбіотичного засобу квертуліну попереджало розвиток НАСГ.