Cytokines changes in the pathogenesis of acute or exacerbated chronic pancreatitis considering the etiology and gender

Abstract

To study the content of certain cytokines in the serum of patients with acute or exacerbated chronic pancreatitis and, considering the etiological factor and sex, 181 patients have been examined. The study revealed the most pronounced increase in the production of proinflammatory TNF- α 2.47 times with a compensatory increase of anti-inflammatory cytokine IL-4 6.77 times, which is exacerbated by alcohol genesis (the content increase of IL-4 8.98 times). For acute alcoholic edematous pancreatitis the concentration increase of IL-1β with the predominant increase of IL-4 confirms the activation of humoral immunity. The course of acute biliary edematous pancreatitis is accompanied by the higher levels of systemic inflammatory reactions and is characterized by the higher contents of TNF-α by 41.4% than of alcoholic genesis, at the lower concentrations of IL-4 by 43.8%. For biliary edematous pancreatitis the persons with exceeding standards of IL-1β ( χ2=9.52, p=0.002) are more likely to occur by 16.74%, with no significant difference in the frequency of TNF-α and IL-4 considering the etiology of pancreatitis. Female gender is not associated with the increased levels of IL-1β under alcoholic or biliary acute edematous pancreatitis and is a potential factor in the protection of immune disorders.