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dc.contributor.authorIeremenchuk, I.V.-
dc.contributor.authorTodoriko, L.D.-
dc.contributor.authorSlyvka, V.I.-
dc.contributor.authorIlchyshyn, T.I.-
dc.date.accessioned2018-06-25T06:53:44Z-
dc.date.available2018-06-25T06:53:44Z-
dc.date.issued2015-
dc.identifier.otherУДК 616.24-002.5-097-07-085.28-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13924-
dc.description.abstractOne of the reasons for worsening the epidemiological situation is the change of biological properties of bacilli, the failure of the first and the second courses of chemotherapy, interrupted treatment, relapse tuberculosis (TB), unadequit treatment, contact with patients drug resistant tuberculosis insufficient effectiveness of existing TB drugs [3,7 ]. Production of IL-6 and IL-10 in TB patients is independent of drug resistance, but increases in response to increased synthesis of endotoxins by MBT; the magnitude of endogenous intoxication and cytotoxic hypoxia creates prerequisites for the development of drug resistant strains. The IL-18/IL-10 ratio in these patients characterizes the increase in severity of the patient's state, the spread of inflammation processes in the lungs and the development of drug resistance; there is a significant bulk of the Tx-lymphocyte type 2 (CD4+), which indicates the development of deep gap in cell-mediated immune response and prevalence of an ineffective anti-inflammation immune activation.ru_RU
dc.language.isoenru_RU
dc.publisherКлінічна та експериментальна патологіяru_RU
dc.subjecttuberculosisru_RU
dc.subjectmultidrug-resistantru_RU
dc.subjectinterleukinsru_RU
dc.subjectтуберкульозru_RU
dc.subjectмультирезистентний туберкульоз легеньru_RU
dc.subjectінтерлейкіниru_RU
dc.subjectтуберкулезru_RU
dc.subjectмультирезистентный туберкулез легкихru_RU
dc.subjectинтерлейкиныru_RU
dc.titleIndicators of cytokine regulation in patients with multidrug-resistant pulmonary tuberculosisru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра фтизіатрії та пульмонології

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