Condition of rat' liver with experimental immunodeficiency

Abstract

Aim of investigation is to determine the liver condition of rats with experimental immunodeficiency. Immune deficiency (ID) in rats was induced by the injection of the cytostatic cyclophosphamide. The presence of ID was determined by lymphocytes levels (in the blood) and lysocyme (in the serum and liver). The presence of hepatitis was identified by the levels of biochemical markers of liver inflammation (MDA, elastase) and cholestasis (ALP) as well as by the level of "liver markers" (ALT, bilirubin, alkaline phosphatase - ALP) in serum. Cyclophosphamide reduces the lymphocyte and lysocyme levels, and increases hepatic levels of inflammatory markers and cholestasis, and serum levels of "liver markers". Cyclophosphamide causes the development of immunodeficiency and hepatitis.