Effect of melatonin on the activity of marker enzymes in the neuronal plasmatic membranes under conditions of acute hypoxia and varying photoperiodic duration

Abstract

The effect of a single-shot intraperitoneally administration of melatonin in a dose of 1 mg/kg on the activity of Na+, K+ATPase and 5'nucleotidase (5'N) in the forebrain of juvenile male white rats has been investigated under conditions of acute hypoxia. Such studies have been carried out against a background of a varying duration of the photoperiod during one week. It has been established that constant darkness prevents an inhibition of the activity of Na+, K+ ATPase caused by acute hypoxia inducing and promoting an activation of 5'N. The administration of melatonin likewise constant darkness against a background of acute hypoxia prevents a decrease of the activity of Na+, K+ATPase and increases the activity of 5'N.