Pathogenesis of kidney and liver lesions under conditions of 2,4-dinitrofenol administration

Abstract

From the positions of probative medicine the work presents theoretical substantiation and a new approach to solve the scientific task concerning early pathogenesis mechanisms of pseudohepatorenal syndrome as the basis to deteriorate the course of kidney and liver failure with breaking oxidative phosphorylation under conditions of 2,4-dinitrofenol administration. The experiments were conducted on 120 albino outbred male rats with the body weight of 0,16-0,20 kg fed on low-sodium diet with tissue hypoxia modeling.