Jones-matrix tomography of biological tissues phase anisotropy in the diagnosis of uterus wall prolapse

Abstract

The work consists of two parts. In the first part - we mapped a distribution of optical activity and birefringence in polycrystalline networks of biological tissues. The Jones-matrix formalism is used for accessible quantitative description of these types of optical anisotropy. We demonstrate that differentiation of polycrystalline networks of biological tissues can be performed based on the statistical analysis of distribution of rotation angles and phase shifts associated with the optical activity and birefringence, respectively. In the second part we defined - practical operational characteristics, such as sensitivity, specificity and accuracy of Jones-matrix reconstruction of optical anisotropy were identified with the special emphasis on biomedical application, specifically for differentiation of two types of pathology: prolapse and albuminuria.