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DC Field | Value | Language |
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dc.contributor.author | Koloskova, O.K | en |
dc.contributor.author | Bilous, T.M. | en |
dc.contributor.author | Bilyk, G.A. | en |
dc.contributor.author | Lobanova, T.O. | en |
dc.contributor.author | Dikal, M.V. | en |
dc.contributor.author | Bilous, V.V. | en |
dc.date.accessioned | 2017-10-18T12:05:11Z | |
dc.date.available | 2017-10-18T12:05:11Z | |
dc.date.issued | 2017 | |
dc.identifier.other | 10.4103 | |
dc.identifier.uri | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/13041 | |
dc.description.abstract | This study investigated to detect the content of remodeling markers of the respiratory tract in the exhaled breath condensate (EBC) of children with bronchial asthma (BA). Materials and Methods: The study was in clinical groups of children with BA were formed on the indices in sputum supernatant: the Group I ‑ “a high risk group” of bronchial remodeling (37 patients with vascular endothelial growth factor (VEGF) more than 80 ng/ml, and matrix metalloproteinase‑9 (MMP‑9) more than 5.2 ng/ml), the Group ІІ ‑ “a moderate risk” of bronchial remodeling (41 patients with VEGF more than 80 ng/ml, and MMP‑9 <5.2 ng/ml, or VEGF <80 ng/ml, and MMP‑9 more than 5.2 ng/ml), the Group ІІІ ‑ “a low risk” of bronchial remodeling (38 patients with VEGF did not achieve 80 ng/ml, and ММР‑9 <5.2 ng/ml). Results: The results obtained enable to believe that in EBC of children with a high risk of bronchial remodeling was higher azoalbumin olysis (1.8 ml/h comparison of Group II ‑ 1.5 ml/h, P = 0.038, and Group III ‑ 1.4 ml/h, P = 0.007), high catalase activity (81.26 comparison of other group ‑ 50.7, P = 0.06, and 47.07, P = 0.052 μmol/min/mg of protein). Furthermore, in the clinical Group I, the content of nitrogen monoxide metabolites (53.5 mcmol/L) comparison of Group II of children (48.7 mcmol/L, P = 0.28) and the Group III (41.7 mcmol/L, P = 0.085). Conclusions: In children with a “high risk” of respiratory tract remodeling more significant inflammatory process in the bronchi is found than in children with a “low risk.” | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | J Med Sci | ru_RU |
dc.relation.ispartofseries | №37(4).; | |
dc.subject | Bronchial asthma | ru_RU |
dc.subject | children | ru_RU |
dc.subject | exhaled breath | ru_RU |
dc.subject | condensate | ru_RU |
dc.subject | bronchial remodeling | ru_RU |
dc.title | Content of Markers of Respiratory Tract Remodeling in Exhaled Breath Condensate in Children Suffering from Bronchial Asthma | ru_RU |
dc.type | Article | ru_RU |
Appears in Collections: | Статті. Кафедра педіатрії та дитячих інфекційних хвороб |
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File | Description | Size | Format | |
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10. jmedsci_11_17R9.pdf | 315.02 kB | Adobe PDF | View/Open |
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