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DC Field | Value | Language |
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dc.contributor.author | Кoloskova, О.К. | - |
dc.contributor.author | Bilous, Т.М. | - |
dc.contributor.author | Lomakina, Y.V. | - |
dc.date.accessioned | 2017-10-18T08:03:42Z | - |
dc.date.available | 2017-10-18T08:03:42Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1512-2778 | - |
dc.identifier.uri | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12999 | - |
dc.description.abstract | Accordingtoatopicalup-to-datedefinitionsuggestedinPRACTALL [1], exercise-inducedbronchialasthma (EIBA) isaseparatevariantofbronchialasthma (BA) whentransientbronchialobstructionassociatedwithphysicalactivityisdetected. ItsoccurrenceinchildrenwithoutBAisdeterminedas “bronchialspasm” or “exercise-inducedbronchialconstriction”[2, 3]. Exercise-inducedbronchialspasm (EIBS) isobjectivelydeterminedas10% reductionofFEV1 (forcedexpiratoryvolumein 1 second) andmorethanthatoftheinitialvalueafterappropriatebronchialprovocationtest[4, 5]. AlthoughthemostfrequenttriggerofEIBAisintensiveandrelativelylongphysicalactivity, thisdiseaseischaracterizedbyamulti-triggercharacterofexacerbationsalteringthecourseofBAintomoresevereone[6]. According to these authors in addition to physical activity the following triggers of BA are: meteorological factors (32,9%), acute respiratory viral infection (ARVI) of effect of cold (22,3%), pollen (19,0%), animal epidermis (14,4%), house dust (11,0%), and exposure to tobacco smoke (8,0%). AtthesametimetherearecertaindataprovingtheroleofageneticcomponentinthedevelopmentofBAasamultifactorialdisease[7-8]. These investigations deal with the study of the role of deletion gene polymorphism coding the activity of glutathione-S-transferase for the course of BA in children [9-10]. Atthesametime, itshouldbenotedthatpathogenesisofBAphenotypehasnotbeenstudiedcompletelyyet, whichisevidentinunsolvedquestionsofdiagnosticsandindividualizedapproachestotreatment. Modernscientificliteratureavailabledoesnotpresentsufficientevidenceconcerningthevalueofgeneticcomponent, anddeletionsofGSTT1andGSTM1 genesin particular, and/or mutation polymorphism of еNOSgene in the formation of exercise-induced bronchial spasm. | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | Georgian Respiratory Journal | ru_RU |
dc.relation.ispartofseries | Vol. 13, N. 2.; | - |
dc.subject | children | ru_RU |
dc.subject | exerciseinducedbronchialasthma | ru_RU |
dc.subject | genepolymorphism | ru_RU |
dc.title | Significance of certain genotypic characteristics to form exercise-induced bronchial asthma in children | ru_RU |
dc.type | Article | ru_RU |
Appears in Collections: | Статті. Кафедра педіатрії та дитячих інфекційних хвороб |
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9. стаття грузия 2017 2.pdf | 348.63 kB | Adobe PDF | View/Open |
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