Severe bronchial asthma in children with exercise-induced bronchospasm

Abstract

Based on a complex examination 46 of schoolchildren suffering from severe asthma, we established that greater proportion of schoolchildren with exercise-induced asthma was with symptoms of mucospin hypereosinophilia (average content of eosinophilic granulocytes over 8 %) than children suffering from severe type of the disease, with no signs of exercise-induced bronchoconstriction. The bronchi of the schoolchildren with severe exercise-induced bronchial asthma are hyperresponsive to histamine, significantly greater proportion of patients with severe airway hypersensitivity to histamine (PC20H<0,5 mg/ml) among the children exercise-induced asthma than those without phenomena of exercise-induced constriction.