Signs of inflammation in the airways in children with exercise induced bronchial asthma

Abstract

The study basing on examination of 102 children with bronchial asthma defines indices of inflammatory activity in the airways and sets the diagnostic value of these indices as tests for verification exercise-induced bronchial asthma. The children with no signs of exercise-induced asthma compared to patients having them, were shown to experience some changes in the exhaled breath condensate, indicating a higher activity of inflammation in the airways. The content of nitrogen monoxide metabolites less than 50 mcmol/L or markers of proteolytic activity by azocol lysis less than 0.2 ml/hour in pulmonary expiration products increase the chances of having exercise-induced bronchial asthma phenotype with these tests sensitivity within 66.7-75.7%.