TREATMENT OF NECROTIC SUPPURATIVE LESIONS IN PATIENTS WITH DIABETES MELLITUS USING REGIONAL PROLONGED OZONE THERAPY

Abstract

In patients with ischemic-gangrenous form of diabetic foot syndrome intra-arterial injection of ozone-containing physiological saline made according to Seldinger method promotes decrease of glycemia level and potentiates a positive therapeutic effect of a comprehensive treatment of this category of patients. Stimulation of the macrophage functional activity under ozone effect as well as availability of destructive changes in the cells without necrotizing lesions can be explained by involvement of apoptosis mechanism as a positive factor in the regulation of local homeostasis on the final inflammatory (exudative) phase of a wound process.