Peculiarities of carbohy drate metabolism of patients with arterial hypertension against the background of abdominal obesity depending on Pro197Leu polymorphism of the GPX1 gene

Abstract

Pro197Leu polymorphism of the gene GPX1 in 102 patients with arterial hypertension and concomitant abdominal obesity and 97 healthy individuals have been studied. Disorders of distribution of genotype frequencies comparing with the control group at the expense of the reduction of Pro/Pro genotype frequency have been found in the main group. Analyzing the data, the increasing risk of disorders in the GPX 1 activity in patients with Pro/Leu and Leu/Leu variants of polymorphism comparing with homozygotes for the "wild" allele at 4,7 and 6,9 times respectively, had been revealed. Analyzing the changes of carbohydrate metabolism depending on the Pro197Leu polymorphism of the gene GPX1, it was established that in patients with Leu/Leu genotype the production of immunoreactive insulin, leptin, C-peptide, HOMA-IR increased significantly. Thus, Pro-allele possesses protective properties as to the reduction in the activity of glutathione peroxidase. Insulin and leptin resistance develop in the carriers of Leu-allele, wich causes disturbances in carbohydrate metabolism.