Please use this identifier to cite or link to this item: http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12045
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBoychuk, T.M.
dc.contributor.authorKmet, T.I.
dc.contributor.authorTkachuk, S.S.
dc.date.accessioned2017-02-09T10:53:43Z
dc.date.available2017-02-09T10:53:43Z
dc.date.issued2016
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12045
dc.description.abstractThe peculiarities of anti-apoptotic mechanisms in the nerve and glial cells of the parietal lobe cortex are studied by the density changes of Bcl-2+-cells location and concentration of Bcl-2 protein in them in rats with diabetes mellitus in the dynamics of ischemic-reperfusion cerebral injury. Bilateral carotid ischemia-reperfusion is found to inhibit anti-apoptotic reaction of nerve cells of the parietal lobe cortex in the early and late post-ischemic periods at the expense of decreased number of Bcl-2+-cells and concentration of Bcl-2 protein in them. In glial cells during the early period of ischemic-reperfusion injury the activity of anti-apoptotic processes intensifies to some extent by means of increased concentration of Bcl-2 protein in them, and on the 12th day the activity of anti-apoptotic processes decrease at the expense of reduced amount of Bcl-2+-cells and the content of Bcl-2 protein in them. Three-month streptozotocin-induced diabetes increases the location density of positive by protein Bcl-2 nerve cells in the parietal lobe cortex without influencing on the location density of Bcl-2+-glial cells and concentration of Bcl-2 protein in them. 20-minute ischemia with one-hour reperfusion in animals with diabetes mellitus considerably enhances anti-apoptotic potential of glial cells in the parietal lobe cerebral cortex at the expense of increased amount of Bcl-2+-cells and the concentration of Bcl-2 protein in them without reliable effect on these indices in nerve cells. On the 12th day of ischemic-reperfusion period in rats with diabetes mellitus, the intensity of anti-apoptotic processes in general decreases both in nerve and glial cells of the parietal lobe cortex.ru_RU
dc.language.isoenru_RU
dc.publisherThe Pharma Innovation Journalru_RU
dc.subjectdiabetes mellitusru_RU
dc.subjectcarotid ischemia-reperfusionru_RU
dc.subjectparietal lobe cortexru_RU
dc.subjectBcl-2 proteinru_RU
dc.titleReaction of Bcl-2+ cells of the parietal lobe cortex of rats with experimental diabetes mellitus to ischemia-reperfusionru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра гігієни та екології

Files in This Item:
File Description SizeFormat 
Pharma In 5-5-19-287.pdf183.46 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.