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Title: | Reaction of Bcl-2+ cells of the parietal lobe cortex of rats with experimental diabetes mellitus to ischemia-reperfusion |
Authors: | Boychuk, T.M. Kmet, T.I. Tkachuk, S.S. |
Keywords: | diabetes mellitus carotid ischemia-reperfusion parietal lobe cortex Bcl-2 protein |
Issue Date: | 2016 |
Publisher: | The Pharma Innovation Journal |
Abstract: | The peculiarities of anti-apoptotic mechanisms in the nerve and glial cells of the parietal lobe cortex are studied by the density changes of Bcl-2+-cells location and concentration of Bcl-2 protein in them in rats with diabetes mellitus in the dynamics of ischemic-reperfusion cerebral injury. Bilateral carotid ischemia-reperfusion is found to inhibit anti-apoptotic reaction of nerve cells of the parietal lobe cortex in the early and late post-ischemic periods at the expense of decreased number of Bcl-2+-cells and concentration of Bcl-2 protein in them. In glial cells during the early period of ischemic-reperfusion injury the activity of anti-apoptotic processes intensifies to some extent by means of increased concentration of Bcl-2 protein in them, and on the 12th day the activity of anti-apoptotic processes decrease at the expense of reduced amount of Bcl-2+-cells and the content of Bcl-2 protein in them. Three-month streptozotocin-induced diabetes increases the location density of positive by protein Bcl-2 nerve cells in the parietal lobe cortex without influencing on the location density of Bcl-2+-glial cells and concentration of Bcl-2 protein in them. 20-minute ischemia with one-hour reperfusion in animals with diabetes mellitus considerably enhances anti-apoptotic potential of glial cells in the parietal lobe cerebral cortex at the expense of increased amount of Bcl-2+-cells and the concentration of Bcl-2 protein in them without reliable effect on these indices in nerve cells. On the 12th day of ischemic-reperfusion period in rats with diabetes mellitus, the intensity of anti-apoptotic processes in general decreases both in nerve and glial cells of the parietal lobe cortex. |
URI: | http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/12045 |
Appears in Collections: | Статті. Кафедра гігієни та екології |
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Pharma In 5-5-19-287.pdf | 183.46 kB | Adobe PDF | View/Open |
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