Autofluorescent polarimetry in diagnostics of endometriosis and infertility

Abstract

A new information about optical technique in diagnostics for the endometrium structure has been proposed. The model of Mueller-matrix description of mechanisms responsible for optical anisotropy of these objects (optical activity, birefringence as well as linear and circular dichroism) has been suggested. The ensemble of informationally topical azimuthally stable Mueller-matrix invariants has been determined. Using the statistical analysis of the distribution parameters, the objective criteria for differentiation of endometrium taken from healthy women and patients with endometriosis were determined. From the viewpoint of probative medicine, the operational characteristics (sensitivity, specificity and accuracy) of the information-optical method applied to Mueller-matrix mapping of endometrium histological section have been found and its efficiency in diagnostics of endometriosis and infertility has been demonstrated.