Changes of glutathione system parameters in blood of alloxan diabetic rats under the influence of melatonin in condition of light around-the-clock

Abstract

Insertion of melatonin for 7 days helped to reduce 1,7 times basal glucose level in the group of animals with overt diabetes in condition of light around-the-clock. Activity of glucose-6-phosphate dehydrogenase, glutathione peroxidase and glutathione reductase in the blood of rats with overt diabetes was on 45%, 32%, and 30% respectively lower than in control rats that were under artificial equinox. In rat blood with overt and latent diabetes occurred reduction of reduced glutathione content on 23% and 42% respectively compared with those of control. Insertion of melatonin to diabetic rats helped in normalization of parameters.