Effect of melatonin on the functioning of glutathione system in the liver of alloxan diabetic rats in lighting conditions around the clock

Abstract

Abstract. Insertion of melatonin for 7 days helped to reduce 1,7 times basal glucose level in the group of animals with overt diabetes. Activity of glucose-6-phosphate dehydrogenase, glutathione peroxidase and glutathione reductase in the liver of rats with overt diabetes was on 47%, 33%, and 35% respectively lower than in control rats that were under artificial equinox. In rat liver with overt and latent diabetes occurred reduction of reduced glutathione content on 25% and 41% respectively compared with those of control. Insertion of melatonin to diabetic rats helped in normalization of parameters.