Effect of DIO1 and GPX1 gene polymorphism on the functional condition of the endothelium in patients with chronic diffuse liver disease

Abstract

In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule-1 type in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of NO metabolites in the carriers of LeuLeu-genotype. Examination of the indices of cellular adhesion and functional endothelial state in patients with chronic diffuse liver diseases did not reveal their dependence on the distribution of A/C polymorphism of DIO1 gene.