Peculitaries of indeces of endothelial function in patients with metabolic syndrome depending on Pro197Leu polymorphism of the GPX1 gene

Abstract

Pro197Leu polymorphism of the gene GPX1 have been studied in 102 patients with metabolic syndrome (MS) and 97 healthy individuals. The vascular endothelial growth factor (VEGP) and number of circulating desquamated endothelial cells were investigated in 102 patients, 20 healthy individuals made control group. Analyzing the data, the growth of risk of disorder in the GPX1 activity in patients with Pro/Leu and Leu/Leu variants of polymorphism comparing with homozygotes for the «wild» allele at 4,7 and 6,9 times respectively had been revealed. Individuals with Leu/Leu genotype had significantly higher level of VEGF expression and endothelial desquamation intensity compared with the persons with Pro/Pro genotype. Consequently, in patients with metabolic syndrome the risk of glutathione peroxidase 1 activity reduction is associated in a dose-dependent manner with the presence of «mutant» Leu-allele; while homozygous for the «wild» Pro-allele had insignificantly lower risk of this disorder. The presence of Leu-allele in genotype of patients with metabolic syndrome is associated with functional state of the endothelium violation.