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dc.contributor.authorChympoy, K.A.-
dc.contributor.authorPashkovska, N.V.-
dc.contributor.authorGarasdyuk, O.I.-
dc.contributor.authorPavlyukovich, N.D.-
dc.date.accessioned2016-05-26T09:35:31Z-
dc.date.available2016-05-26T09:35:31Z-
dc.date.issued2014-
dc.identifier.urihttp://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/10882-
dc.description.abstractPatients with chronic diffuse of liver disease have a violation of thyroid homeostasis in the form of reduction of free triiodothyronine in the blood serum, as well as thyroid stimulating hormone increasing content and of free thyroxin. In patients with chronic diffuse liver diseases there is a relation between the expression of Pro197Leu polymorphism of GPX1 gene and indices of cellular adhesion, which is revealed by a reliably higher content of soluble intercellular adhesion molecule type 1 in the blood serum in homozygotic carriers of Leu-allele. Changes of the endothelial functional state in patients with chronic diffuse liver diseases are associated with Pro197Leu polymorphism of GPX1 gene, which is proved by a reliably higher index of desquamated endotheliocytes amount and lower level of nitric oxide metabolites in the carriers of LeuLeu-genotype.ru_RU
dc.language.isoenru_RU
dc.publisherМіжнародний ендокринологічний журнал. – 2014. – №1(57). – С.53-56.ru_RU
dc.subjectсhгоniс diffuse liver diseaseru_RU
dc.subjectthyroid homeostasisru_RU
dc.subjectpolymorphismru_RU
dc.subjectendotheliumru_RU
dc.subjectхронические диффузные заболевания печениru_RU
dc.subjectтиреоидный гомеостазru_RU
dc.subjectполиморфизмru_RU
dc.subjectэндотелийru_RU
dc.subjectхронічні дифузні захворювання печінкиru_RU
dc.subjectтиреоїдний гомеостазru_RU
dc.subjectполіморфізмru_RU
dc.subjectендотелійru_RU
dc.titleGenetic determinism of the functional condition of the endothelium in patients with chronic diffuse liver disease and disoders of thyroid homeostasisru_RU
dc.typeArticleru_RU
Appears in Collections:Статті. Кафедра клінічної імунології, алергології та ендокринології

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