Peculiarities of spirometric indices in schoolchildren with bronchial asthma, depending on their atopic status

Abstract

In article on based analysis of spirometric indicators was researched the peculiarities of nonspecific bronchial hyperreactivity depending on the atopic status of school-age children. To identify the degree of atopy anamnestic atopic status and skin allergic tests were used. Children with atopic asthma characterized by tendency to expressive bronchial lability mostly due to bronhodilation response to short-acting β2-agonists and expressive airway hyperresponsiveness to histamine. However the verification of atopic asthma phenotype in children with bronchial lability index and the index of bronchodilation was characterized by high specific with low sensitivity. So, use markers of nonspecific bronchial hyperreactivity to confirmation atopic asthma phenotype relative nonatopic makes sense only in combination with other clinical, laboratory and intsrumental indices that reflect the main characteristics of the disease.