Impact of melatonin on the activity of glucose-6-phosphatase in the liver of alloxandiabetic and tetrachlormethane-intoxicated rats exposed to light deprivation

Abstract

The paper demonstrates that the level of basal glycemia in the blood and the activity of glucose-6-phosphatase in the liver of alloxan diabetic rats with overt diabetes increase respectively compared with the control value. Toxic hepatitis decreases glucose-6-phosphatase activity in the liver. Rats exposed to light deprivation during the experiment room lighting (500Lk, fluorescent lighting), and the absolute round the clock darkness and under photoperiod 12 hour light : 12 hours dark. Exogenous melatonin normalizes impaired due alloxan diabetes and tetrachlormethane hepatitis glucose-6-phosphatase activity in rat liver independent from type of illumination.