Influence of Short-Term Inhalations of High-Concentrated Oxygen Adding of Chamomile Oil to the State of Local Immunity at Sore Throat in Adults

Abstract

Abstract: The article considers the efficacy of use short-term inhalations of high-concentrated oxygen with the addition of chamomile oil on the state of local immunity in adults with sore throat. Materials and methods: The study involved 35 patients aged 25 to 40 years (mean - 34.5 ± 5.71 years, 20 women, and 15 men) with a diagnosis sore throat. Observed were randomized into 2 groups: in group 1 the inhalations with high concentrated oxygen (n=18) were used, in group 2 is treated by inhalations of high concentrated oxygen with Chamomile oil (n=17). Inhalation was conducted with 3 breathing per minute three times (totally 3 minutes) twice per day. The efficacy of therapy was determined by the period of the decrease in severity clinical manifestations and their complete disappearance. The results of the study: The reason for the treatment in all patients was an increase in body temperature to 37.5-38.9°C, the presence of symptoms of intoxication, varying severity of sore throat, a feeling of dryness/sore throat and dry cough. Patients were self-evaluated the severity of sore throat at the period of treatment, at 3.8 ± 0.78 points in group 1 and 3.9 ± 0.86 points in group 2, difficulty in nasal breathing - at 4.1 ± 0.96 points and 4.2 ± 0.85 points, respectively; the severity of hyperemia - by 4.9 ± 0.30 points and 4.8 ± 0.46 points; an increase in tonsils - by 2.4 ± 0.40 and 2.3 ± 0.53 points in groups 1 and 2. In 17.6% people of the 2-nd group, already on the 3rd day, the pharyngoscopic picture completely normalized, while in the 1-st group this result was not attained. By the 4th day of observation, pharyngoscopic signs were absent in 41.2% of patients of the 2nd group and only in 16.7% of people of the 1st group. On the 5th day during the oropharyngeal examination, 55.6% of the 1-st group examined retained mild hyperemia of the mucous membranes of the palatine arches and small tongue, while in the 2nd group this symptom was recorded only in 17.6% of cases. According to the scoring, until the end of the observation period (5-7 days) in both groups - with the Oxygen Breathing Mixture Natural and Oxygen Breathing Mixture Sea Minerals Chamomile inhalations, hyperemia in the oropharynx significantly decreased. The effectiveness of the Oxygen Breathing Mixture Sea Minerals Chamomile inhalations was significantly reduced and the symptoms exceeded the effectiveness of Oxygen Breathing Mixture Natural by 3.5 times (p <0.05). The severity of pain in the follow-up dynamics decreased to 1.7 ± 0.18 points in the 1st group and 1.3 ± 0.15 in the 2nd group (p <0.05). The therapeutic effectiveness of Oxygen Breathing Mixture Sea Minerals Chamomile exceeded the efficiency of Oxygen Breathing Mixture Natural by 30.8%. A significant improvement in nasal breathing was observed on the 5th day of observation - up to 1.7 ± 0.43 points in group 2 versus 2.8 ± 0.51 points in group 1 (p <0.05), with the effectiveness of Oxygen Breathing Mixture Sea Minerals Chamomile-64.7%. Symptoms of intoxication and pharyngoscopic signs of the inflammatory process in patients of the 2-nd group stopped on average 1.5 days faster compared with patients of the 1st group. The level of sIgA in saliva tended to normalize (from 0.18 ± 0.08 to 0.21 ± 0.09 g / l, p> 0.05) in the group 1. The normalization of the content in the group 2 was observed saliva secretion of an initially low level of sIgA (from 0.16 ± 0.03 to 0.34 ± 0.06 g / l, p <0.05). The total duration of acute respiratory viral infections in patients receiving Oxygen Breathing Mixture Sea Minerals Chamomile was on average 3 days shorter than in patients of the 1st group.