Please use this identifier to cite or link to this item: http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9748
Title: POLYFUNCTIONAL PYRAZOLES. 9*. SYNTHESIS OF 1-ALKYL(ARYL)-3-[4-(HYDROXYMETHYL)-1Н-PYRAZOL-3-YL]UREAS
Authors: Bratenko, M.K.
Barus, M.M.
Rotar, D.V.
Vovk, M.V.
Keywords: 4-hydroxymethylpyrazole-3-carbonyl azides
(pyrazol-3-yl)ureas, pyrazolo[3,4-d][1,3]ox-azines
intramolecular cyclization
Issue Date: 2014
Publisher: Chemistry of Heterocyclic Compounds
Series/Report no.: Vol. 50, No. 9;P.1252-1258
Abstract: We have developed an effective method for the preparation of 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas based on the interaction of 4-hydroxymethylpyrazole-3-carbonyl azides with primary aliphatic and aromatic amines under the conditions of Curtius reaction. In the absence of amines in the reaction mixture, in situ generated 4-hydroxymethyl-3-isocyanatopyrazoles underwent intramolecular cyclization to pyrazolo[3,4-d][1,3]oxazin-6(4Н)-ones. The latter showed a tendency to form 1-alkyl(aryl)-3-[4-(hydroxymethyl)-1Н-pyrazol-3-yl]ureas in the presence of amines.
URI: http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/9748
Appears in Collections:Статті. Кафедра медичної та фармацевтичної хімії

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