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Title: A characteristic of the effects of melatonin and epithalon on the state of c-fos gene in the neurosecretory nuclei of the hypothalamus in an experiment
Authors: Bulyk, Roman Yevgenovich
Pishak, Vasil Pavlovich
Lomakina, Yulia Vyacheslavivna
Keywords: c-Fos
paraventrivular nuclei
Issue Date: 2011
Publisher: Клінічна анатомія та оперативна хірургія. -Т.10, №2
Abstract: It has been established that the expression of the c-Fos protein in animals under the normal conditions of alternating lighting and darkness demonstrated a clear-cut circadian character (with a highly daily level). Under the conditions of a light stress the daily parameter of the index of the c-Fos content in the lateral macrocellular subnuclei of the paraventricular nucleus (lm PVN) of rats was lower by 33,0%, whereas the nocturnal one approximated tj the control values. Melatonin injections (0,5 mg/kg) to animals stressed by light manifested at 02.00 p.m. by an increase of the index of the c-Fos protein content in the lm PVN almost twice as much as compared with the fingers of an experiment on stressed rats without introducing the hormone and a normalization of the circadian dynamics of its expression. While using epithalon tetrapetide (0,5 mkg/kg), an increase of the index of the c-Fos protein concentrationwas detected in the structure at night relative to rats with an epiphysial hypofunction without epithalon therapy. Such an effect of the medication was not registered in the day-time.
ISSN: УДК 612.826.4:612.017.2
Appears in Collections:Статті. Кафедра медичної біології та генетики

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